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30 Luglio 2020

The Remarkable Rise of Higher Education in Qatar

A major part of Qatar’s National Vision 2030 is to develop a knowledge-based economy and a “world-class educational system.”

By analyzing data from LinkedIn, we are starting to see some promising results.

For those who don’t know, LinkedIn is a place where people post their resume and make connections and also where employers post job openings and recruit. The number of people on LinkedIn is 600 million; for comparison, that’s bigger than Twitter.

Why are we talking about LinkedIn? Hang on, you’ll see in a minute.

LinkedIn was started in the U.S. in 2003, expanded overseas in 2008 to the UK and eventually around the world. In 2015, they launched in Arabic for the first time, and now it’s widely used in the GCC.

Based on our research, we uncovered a surprising statistic…

There are more university graduates in Qatar per capita than in the UK. 👩‍🎓

That was definitely not the case prior to the creation of Education City.

Education City has a campus several times larger than the Municipality of Monaco
Education City is the flagship project of Qatar Foundation, which began in 1995 by the former ruler of Qatar, His Excellency Sheikh Hamad bin Khalifa Al Thani and Her Highness Sheikha Moza bint Nasser who is the current Chairperson. In developing Education City, they sought to build a societal infrastructure to diversify from a resource-based economy to a knowledge-based economy.

Hello Qatar briefly spoke with former U.S. Ambassador to Qatar, Patrick Theros, about the early days of Education City. Topics discussed included how to get an American college education without the difficulty of going to the U.S., how to determine success, and how the idea of branch campuses in Qatar constitutes, “The best thing American higher education has done in my lifetime.”

Students who are accepted at one of the many universities are allowed to study across universities – bringing to light the idea of a multiversity. The branch campuses strive to ensure that students receive the same degree and diploma from the University home campus as the curricula are identical. The biggest difference is the location.

Centrally located between East and West, Qatar offers 80 countries a visa-free waiver program as opposed to only 39 countries offered by the U.S.

In addition to Qatar University, founded in 1973, there are several international Universities in Qatar. Of the 16 Universities shown in the image, 9 are inside Education City (HBKU, Georgetown, Northwestern, Cornell, Texas A&M, VCU, Carnegie Mellon, UCL, and HEC Paris).

The Washington Post referred to Education City as an “Academic Oasis.” With 6 major U.S. universities, Qatar is home to more U.S. college campuses than anywhere outside of North America.

Future Leaders Program

In addition to educating Qatar’s youth, Education City can be a powerful force beyond Qatar’s borders. Imagine if you could embrace the future leaders of countries and introduce them to study at Education City.

How?

Focus on the top-ranked high schools in capital cities. Geofence advertising (see below) makes it possible to disseminate a video about the world-class universities in Education City. These ads can show the video to the smartphones of students at the best schools in the European capitals of Berlin, Brussels, London, Paris, Rome, and Vienna.

How geofencing can be used to raise awareness about Education City
By raising awareness and offering attractive scholarships, Education City will inevitably attract some number of students to study in Qatar. This will help to establish deeper bonds of friendship and enhance relations in immeasurable ways for years to come. To learn more about geofencing contact info@bluefortpr.com

Upon Graduation

Almost 70 percent of Qatar’s higher-education graduates are women, according to the Ministry of Foreign Affairs, and in 2019, Texas A&M in Qatar graduated its 1000th engineer!

n the Workplace

Upon entering the workplace, many graduates take up careers in a variety of fields. The categories of jobs can be segmented into approximately two dozen job codes, according to LinkedIn. For Qatar’s alumni, the most common job categories are: Operations, Business Development, Engineering, Research, IT, Communications, HR, Finance, and Administration.

The companies that have hired graduates from Qatar’s many universities are among the biggest in the world. They include not only local companies such as Qatar Foundation, Qatar Petroleum and Al Jazeera, but also international heavyweights such as Microsoft, Amazon, and Google as well as ExxonMobil, Deloitte, Vodafone, and many more. The image below highlights some of the companies we encountered in our research. For more in-depth information on Qatar’s alumni network contact info@helloqatar.co

As you can see, the alumni not only work in Qatar but across the region and around the world. They are at work on every continent in countries ranging from Canada to New Zealand and many places in between.

22 Luglio 2020

Learning science through gameplay

Spencer Striker and Anto Mohsin, professors at QF partner university Northwestern University in Qatar, are developing a mobile game on contact tracing

When we learned about Hamad Bin Khalifa University Innovation Center’s Rapid Response Call, we quickly saw the potential of designing a mobile game about contact tracing. We liked the idea of learning through gameplay, which enforces the idea that science can be an adventure – thrilling and fun.

During this pandemic, introducing a mobile game about contact tracing, and its underlying scientific principles, is vital as we hope more users will learn about the science of epidemiology, contact-tracing, the complex world of contagions.

I bring to the project my expertise in digital media design while my colleague, Anto Mohsin, brings his expertise in science and technology studies, including how the world of health emergencies and epidemiology is understood by society.

During this pandemic, introducing a mobile game about contact tracing, and its underlying scientific principles, is vital as we hope more users will learn about the science of epidemiology, contact-tracing, the complex world of contagions.

I bring to the project my expertise in digital media design while my colleague, Anto Mohsin, brings his expertise in science and technology studies, including how the world of health emergencies and epidemiology is understood by society.

Spencer Striker is an associate professor-in-residence for communication at Northwestern University in Qatar.
As we developed the game design, we invited Dr. Ali Sultan – renowned epidemiologist – to join the project. And we were thrilled when he agreed to consult on the science.

Our initial inspiration for making an action-adventure, visual novel mobile game was watching and re-watching the movie, Contagion (2011), which shot to relevance when the COVID-19 pandemic suddenly, and seemingly overnight, became a global reality. The initial inspiration was to create an action-packed game that focused on the Kate Winslet and Marion Cotillard character archetypes, who are globe-trotting, Epidemic Intelligence Service officers – “disease detectives” – in the movie.

We got inspired by the Lara Croft meets Sherlock Holmes concept of a brave, brilliant individual taking on a grave, global pandemic, searching the world for the index patient, connecting seemingly disparate dots – confronting fear, both personal and societal – all the while racing against time to find clues to a cure. There’s so much there: high stakes time pressure, compelling character and narrative, perplexing puzzles, and of course the natural gameplay dynamics that emerge from network science and contact tracing.

Through the title character, Dr. Sara, the game will see players use questioning, detective work, and diplomacy to heroically stop the spread of contagions

Inspired by the protagonists in Contagion, we decided to go with a female doctor as the main character of the game. And we thought that using an Arabic name would help build excitement among women, as well as spark an interest in science, medicine, technology, and public health. That’s how we ended with the title of our project: Dr. Sara: Disease Detective.

We’re seeking to introduce a novel mobile game design concept. There are no products currently on the marketplace that simulate the investigative work of Epidemic Intelligence Service officers. Also, our product is different from the contact tracing apps that several governments have designed and rolled out, such as Ehteraz in Qatar. Dr. Sara: Disease Detective will teach users in a narrative-driven, immersive way about the important role Epidemic Intelligence Service officers play in understanding and containing the outbreak of infectious diseases.

Anto Mohsin is an assistant professor-in-residence for the liberal arts program at Northwestern University in Qatar.
Through the title character, Dr. Sara, the game will see players use questioning, detective work, and diplomacy to heroically stop the spread of contagions, while learning about core concepts such as fomites, vectors, R0, and contact tracing. Ultimately, our game will demonstrate how contact tracing requires a human element to work in conjunction with modern digital and communication technologies. We also would like to show that public health issues are multidimensional and draw from wide fields of expertise.

We plan to recruit Northwestern University in Qatar students to the project. We’ve worked with a number of talented young people on other projects in the past, and we see opportunities for them to take on roles such as project management, game design, and game illustration.

Ultimately, we hope that our new mobile game about contact tracing, Dr. Sara: Disease Detective, will get young people excited about the amazing adventure that is science

One of our hopes is that the product will encourage curiosity and a drive for lifelong learning. Ultimately, we hope that our new mobile game about contact tracing, Dr. Sara: Disease Detective, will get young people excited about the amazing adventure that is science.

Spencer Striker is an associate professor-in-residence for communication, specializing in digital media design, at Northwestern University in Qatar.
Anto Mohsin is an assistant professor-in-residence for the liberal arts program at Northwestern University in Qatar, and specializes in science and technology studies.

15 Luglio 2020

QF research institute creates intelligent tech solutions to address pandemic

Dr. Ashraf Aboulnaga says QCRI responded to the pandemic from day one by developing technologies and applications for existing challenges

From the first week of the pandemic, Qatar Computing Research Institute was swift to respond – they developed a system that traces the movement of people based on cell phone data.

Our system helped the health authorities with contact tracing for COVID-19 positive patients, especially in the first few weeks of the pandemic, before the Ehteraz app was deployed

Dr. Ashraf Aboulnaga

“Our system helped the health authorities with contact tracing for COVID-19 positive patients, especially in the first few weeks of the pandemic, before the Ehteraz app was deployed,” Dr. Ashraf Aboulnaga, Senior Research Director at Qatar Computing Research Institute (QCRI), explains.
The Hamad Bin Khalifa University research institute was quick to develop a portfolio of applications and tools to address national and global priorities in the fight against COVID-19, with solutions ranging from digital health tools, analyzing data, and facilitating literature reviews, among many others.

One such solution was to gather data related to social distancing to help policymakers.

Dr. Ashraf Aboulnaga

“Now that people are aware of social distancing and its importance in the way we respond to the pandemic, it is important for users and health authorities to be able to measure and analyze the degree of social distancing and contacts,” Dr. Aboulnaga says.

He highlights the importance of measuring social distancing at the scale of the entire country, such as which places are visited by people more than usual and which are visited less than usual.

“QCRI has developed a web-based dashboard that computes this information based on Google data and displays a map showing the reduction or increase in visits for important locations in Doha. This is valuable data that is used by the health authorities in Qatar,” Dr. Aboulnaga says.

And it is not just Qatar that is benefitting from this data-gathering system. QCRI has partnered with several NGOs to extend this dashboard to other cities such as Kuwait, Beirut, Amman, Nairobi, and Lagos.

The Qatar Foundation research institute has also developed mobile phone apps that use GPS for contact-tracing to ensure quarantined people remain within their quarantine area, as well as an online self-assessment tool that is accessible from the web or mobile phones.

The online self-assessment tool is based on a questionnaire that helps users’ assess their symptoms and decide their next steps, such as seeking medical help

Dr. Ashraf Aboulnaga

“The online self-assessment tool is based on a questionnaire that helps users asses their symptoms and decide their next steps, such as seeking medical help,” Dr. Aboulnaga says.

The tool is a web-based tool and is based on the guidelines laid out by the World Health Organization and Hamad Medical Corporation. A key feature of the self-assessment tool is that it is multi-lingual.

The tool has been very successful, Dr. Aboulnaga says, with 1.3 million visits to date. The tool is available in 11 languages and the two most popular are Arabic and Hindi.

We adapted our technologies to help in identifying rumors and disinformation around COVID-19

Dr. Ashraf Aboulnaga

Besides this, QCRI has also modeled and visualized the evolution of the pandemic. The research institute created a dashboard that summarizes data related to the pandemic in Qatar and the GCC countries which helps predict disease development.

“The dashboard is used by government health authorities in Qatar, and internally within Qatar Foundation,” Dr. Aboulnaga says.

QCRI also strives to address false and inaccurate information that makes its way to social media – a prominent feature of today’s hyperconnected social media age where a lot of disinformation about COVID-19 is created – also known as “infodemic”.

QCRI has a system called Rayyan that facilitates large literature reviews. It is a mature system used by 65,000 users around the world, and it has been used heavily in this pandemic

Dr. Ashraf Aboulnaga

“For the past few years, QCRI has been working on analyzing social media and countering propaganda in the news and media,” says Dr. Aboulnaga. “We adapted our technologies to help in identifying rumors and disinformation around COVID-19. We produce regular reports about social media for the health authorities and provide web-based tools to identify and analyze propaganda.”

Countering COVID-19 requires scientists and public health practitioners to review large amounts of scientific literature and publications with a view to collecting evidence supporting their hypotheses, and to seek answers to relevant questions, Dr. Aboulnaga explains – for example, have any studies demonstrated a link between weather and prevalence of COVID-19?

“QCRI has a system called Rayyan that facilitates large literature reviews. It is a mature system used by 65,000 users around the world, and it has been used heavily in this pandemic,” Dr. Aboulnaga says.

CORD-19 – a data set of over 150,000 scientific articles related to COVID-19 released in the US at the request of the White House and immensely valuable to researchers – is available in Rayyan.

10 Luglio 2020

Global science competition hosted by QF and British Council brings out the best in Qatar’s students

Global science competition hosted by QF and British Council brings out the best in Qatar’s students

Competition highlights importance of science communication

Ideas inspired by everything from the COVID-19 pandemic to science fiction have been outlined by finalists in one of the biggest science communication competitions in the world, as it took place in Qatar for the fifth time.

The national final of FameLab – organized by the British Council and Qatar Foundation member Qatar National Research Fund (QNRF), and supported by the Ministry of Education and Higher Education – saw 21 participants given free rein to choose their own topic and present a scientifically-proven idea to a public audience in the space of just three minutes.

https://www.qf.org.qa/stories/global-science-competition-hosted-by-qf-and-british-council-brings-out-the

 

1 Luglio 2020

Qatar Foundation e Mater Olbia uniti nella ricerca contro il Covid

Aiutare a identificare trattamenti potenzialmente salvavita per il coronavirus, studiando come il sistema immunitario umano risponde al plasma di pazienti che si sono già ripresi dalla malattia: una cura promettente, ma su cui i dati sono attualmente limitati. + con questo obiettivo che dei campioni di plasma provenienti da persone guarite dal Covid-19 sono stati trasportati dal Qatar in Italia, grazie a una partnership tra la Fondazione Qatar, Hamad Medical Corporation e l’Ambasciata d’Italia nel Paese. Il plasma è stato trasportato approfittando di un aereo militare italiano che da Doha doveva riportare a casa dei soldati impegnati con la coalizione anti-Isis a guida americana. I campioni saranno analizzati ora dall’Università Cattolica del Sacro Cuore e dall’Ospedale Mater Olbia in Sardegna. Lo scopo del progetto scientifico Qatar-Italia è dimostrare che il plasma di pazienti convalescenti contiene livelli sufficienti di anticorpi per trattare con successo i malati di Covid-19. “Siamo molto orgogliosi che i principali centri medici e di ricerca italiani e del Qatar lavorino insieme per un progetto che può fare davvero la differenza per le persone e salvare vite umane – sottolinea l’ambasciatore Alessandro Prunas – Questo è un esempio perfetto di come i nostri Paesi possano unire i loro sforzi per rispondere alle problematiche globali e condividere i risultati con la comunità internazionale. La ricerca scientifica è diventata un aspetto fondamentale della nostra cooperazione bilaterale e sono fiducioso che l’Italia e il Qatar presto rafforzeranno ulteriormente il loro impegno nello sviluppo di nuovi progetti che sblocchino il potenziale non sfruttato in questo settore”.

18 Giugno 2020

Intervento di 8 ore per rimuovere tumore cerebrale complesso

L’equipe di Neurochirurgia del Mater Olbia Hospital (Moh), coordinata da Alessandro Olivi, professore e neurochirurgo di fama mondiale e direttore unità operativa complessa di Neurochirurgia Fondazione Policlinico Universitario Agostino Gemelli Irccs e da Giovanni Sabatino, responsabile del Reparto Neurochirurgia dell’Ospedale Mater Olbia, ha effettuato con successo un intervento chirurgico per via craniotomica di asportazione con tecnica microchirurgica di un meningioma del forame magno. L’intervento, molto delicato a causa della collocazione e dell’ingente dimensione del tumore da trattare, è stato effettuato martedì 16 giugno ed è durato più di otto ore.

“La paziente trattata è una signora di 68 anni della provincia di Sassari portatrice dal 2014 di un meningioma localizzato in prossimità del forame magno, a stretto contatto con il tronco cerebrale. L’intervento eseguito rappresenta uno dei più complessi tra quelli che si possono oggi effettuare in neurochirurgia, e questo per un duplice motivo: da una parte la localizzazione profonda della lesione, per cui era molto difficile intervenire, dall’altra la dimensione molto cospicua della massa collocata proprio vicino al tronco cerebrale, dove hanno sede i centri che controllano diverse funzioni vitali, come quelle respiratorie, cardiocircolatorie, dei movimenti oculari, uditive e motorie”, ha spiegato Olivi.

L’indicazione all’intervento chirurgico è arrivata dopo una attenta valutazione multidisciplinare eseguita presso l’Ambulatorio di Neurochirurgia del Mater Olbia Hospital – una struttura moderna e dinamica, nata grazie alla collaborazione fra Qatar Foundation Endowment e Fondazione Policlinico Universitario Agostino Gemelli Irccs – e alla quale la paziente è approdata dopo che gli esami radiologici di follow-up, eseguiti negli ultimi anni, documentavano un progressivo aumento dimensionale del tumore. L’intervento è stato completato con successo e in sicurezza, grazie anche alle più moderne tecnologie offerte dalla nuova struttura ospedaliera olbiese, tra le quali la presenza in sala operatoria di un microscopio di ultima generazione, la Tac intraoperatoria e il monitoraggio neurofisiologico continuo delle funzioni vitali e l’aspiratore ad ultrasuoni.

“La presenza di queste strumentazioni di ultima generazione – sia dal punto di vista radiologico, per studiare in modo dettagliato l’approccio, sia da quello che noi chiamiamo ‘navigazione avanzata’, molto simile come concetto alla navigazione che usiamo per guidare l’auto – ci ha consentito durante l’intervento di identificare e salvaguardare tutte le strutture vitali su cui siamo intervenuti”, ha continuato il neurochirurgo. “Grazie alla Tac intraoperatoria tridimensionale, ad esempio, abbiamo avuto conferma in tempo reale, quando ancora la paziente era in sala operatoria, del buon esito dell’intervento e dell’assenza di complicanze emorragiche. La complessa operazione ha avuto una durata di circa otto ore. La paziente sta ora molto bene. Portata lentamente al risveglio, è stata sin dal giorno dopo in grado di comunicare e svolgere alcune semplici attività”.

Il Mater Olbia Hospital conferma così la sua vocazione a essere, non solo una struttura fondamentale per l’intera Sardegna, ma sempre più polo d’eccellenza e punto di riferimento. “E’ questo un segno molto importante perché il Mater Olbia, grazie a una tecnologia particolarmente sofisticata e a un’organizzazione trasversale e multidisciplinare, ha consentito alla nostra equipe, coordinata anche da Giovanni Sabatino, di portare a termine questo tipo di intervento, tra i più complessi annoverabili in neurochirurgia”, ha concluso Olivi.

dal 23 giugno, ogni mattina, presso il nostro ospedale sarà attivato un ambulatorio Neuro-oncologico in cui sarà possibile eseguire una valutazione ambulatoriale neurochirurgica specifica per la diagnosi, il trattamento ed il follow-up delle patologie tumorali cerebrali e spinali come meningiomi, metastasi, gliomi e neurinomi. Il team della Neurochirurgia del Mater Olbia, si trova da lungo tempo ad affrontare le problematiche relative alla scoperta inaspettata di un tumore cerebrale e allo smarrimento che il paziente può provare nella gestione di una patologia che può presentare differenti aspetti clinici e terapeutici. E’ per questo motivo che l’Ambulatorio di Neurochirurgia Tumorale Cerebrale e spinale si dedica all’assistenza del paziente a 360°, anche grazie alle più moderne attrezzature e ai più sofisticati ausili intraoperatori, al fine di garantire la migliore qualità di cura ed il miglior servizio al cittadino che la Regione Sardegna possa offrire.

12 Giugno 2020

Fase 3, Mater Olbia: al via intesa con Cagliari e Olbia Calcio per assistenza sanitaria

Roma, 11 giu. (Adnkronos Salute) – Il Mater Olbia Hospital (Moh) sosterrà la ricerca e fornirà assistenza sanitaria ai giocatori del Cagliari e dell’Olbia Calcio, nel post-Covid. Una collaborazione “che vuole essere un sostegno e un pieno appoggio da parte di una delle strutture più all’avanguardia della Sardegna. Dopo l’accordo raggiunto nei giorni scorsi con la dirigenza delle due squadre dell’isola, il 5 giugno sono state avviate le prime attività mediche nei confronti dei giocatori e dello staff dell’Olbia Calcio”, si legge in una nota. In particolare, sono stati effettuati i tamponi naso-faringei e gli esami sierologici a giocatori, staff e dirigenti, e completate le visite mediche (spirometria, test da sforzo ed ecocardio) propedeutiche alla ripresa degli allenamenti. Le attività effettuate si inquadrano nell’ambito della collaborazione tra il principale club del Nord Sardegna e l’ospedale nato dalla collaborazione tra Fondazione Policlinico Universitario Agostino Gemelli e Qatar Foundation Endowment. “Questa collaborazione con le due squadre di calcio è un segnale che il Mater Olbia è presente a 360° sul territorio sardo, rivolgendosi a tutta la popolazione così come alle realtà sportive”, ha dichiarato Giovanni Raimondi, amministratore delegato del Mater Olbia, in occasione della firma dell’accordo.I due protocolli di collaborazione prevedono la disponibilità del Moh a fornire assistenza sanitaria, attività di controllo, screening periodici e prestazioni sanitarie specialistiche di alto livello agli atleti delle squadre di calcio. Gli atleti potranno inoltre essere coinvolti in programmi di ricerca scientifica aventi come oggetto pratiche agonistiche sportive. Ogni attività verrà svolta da medici del Moh in stretto collegamento con i medici della squadra che hanno la totale contezza della salute dei loro tesserati. Inoltre, le due società calcistiche e il Moh hanno previsto un orizzonte temporale di 90 giorni per definire un vero e proprio accordo che riguardi non solo gli aspetti relativi al settore sanitario, ma anche una stretta collaborazione sul fonte marketing e commerciale.”Questo protocollo di intesa rappresenta un primo, ma importante passaggio, attraverso il quale ci auguriamo di poter sviluppare una concreta partnership con il Mater Olbia che abbracci le nostre realtà a 360 gradi. La sinergia con il territorio è da sempre una nostra priorità oltre che essere un valore cardine del nostro operato”, ha dichiarato Mario Passetti, direttore generale del Cagliari Calcio.”Siamo orgogliosi di avviare una partnership con un’eccellenza assoluta della città quale è il Mater Olbia – afferma il presidente dell’Olbia Calcio, Alessandro Marino – L’obiettivo è quello di fare sistema sul territorio attraverso la pianificazione di progetti ambiziosi mirati a proiettare Olbia ai livelli che merita nel panorama nazionale sia come comunità che come realtà calcistica”.

Fonte: https://www.affaritaliani.it/notiziario/fase_3_mater_olbia_al_via_intesa_con_cagliari_e_olbia_calcio_per_assistenza_sanitaria-155754.html

21 Maggio 2020

Qatari and Italian experts working on plasma-based therapies to treat patients

Ashraf Siddiqui
Doha
Qatar Foundation Research, Development and Innovation (QF RDI) and the Italian Universities of Rome Tor Vergata and Trieste have established cooperation to collect and analyse genomic information to study
the different impacts of COVID-19 among the population, Italian Ambassador to Qatar HE Alessandro Prunas has said.
In an exclusive with Qatar Tribune, Ambassador Prunas said Qatar Foundation’s Hospital Mater Olbia in Sardinia and Hamad Medical Corporation are also working to find new therapies to treat COVID-19 patients based on the use of plasma from recovered individuals.
He lauded Qatar’s humanitarian support to provide Italy with two fully-equipped field hospitals with capacity of 1,000 beds to treat people with the coronavirus.
Advising his community members in Qatar, the envoy said, “As a result of the social distancing measures, which are crucial in containing COVID-19, we all have to change our daily routine, go out only if strictly necessary, use face masks in public spaces and reduce contacts with other people. Fortunately, thanks to technology, we can be fully operative working remotely and limit staff in workplaces at the minimum level required to ensure continuity of services.”
Talking about his personal contact with the family members back in Italy, he said, “It is not easy not to see them but we have to adopt responsible behaviours to protect who we love most.”
The envoy said he is working from home, holding meetings through telephone and video conferences with Qatari officials and members of the other diplomatic missions to ensure regular coordination on dossiers and plan new activities.
Prunas said that despite the emergency, services go on as usual at the embassy.
He said, “What has changed is how we deliver them to adapt our work flows to this unprecedented situation and the many ideas and projects we have in mind for the future.”
On the likely impact of the pandemic on normal life in future, the Italian envoy said every country would have to deal with the consequences of the pandemic either in social or economic terms.

21 Maggio 2020

Coronavirus: su plasma ‘guariti’ ricerca Qatar, Mater Olbia e Università Cattolica

Plasma da pazienti convalescenti per trattare Covid-19: avviato un progetto di ricerca tra Qatar Foundation Endowment, Hamad Medical Corporation (Doha), Mater Olbia Hospital e Università Cattolica del Sacro Cuore. I risultati della ricerca, che prevede l’arruolamento di 100 donatori e 100 pazienti riceventi, contribuiranno in modo significativo a standardizzare e migliorare la terapia con plasma. Questo approccio, protagonista di numerosi studi in tutto il mondo, potrebbe rappresentare una valida opzione per i pazienti con quadri clinici severi. Alcuni lavori condotti in Cina hanno messo in evidenza le potenzialità di questo trattamento, in analogia a quanto dimostrato in precedenza per altre infezioni virali gravi tra cui Sars e Mers, causate da virus molto simili a Sars-CoV-2, responsabile di Covid-19.

Si ritiene che gli anticorpi presenti nel plasma di pazienti convalescenti possano esercitare un’azione neutralizzante sul virus nei pazienti Covid-19 gravi, contribuendo in modo decisivo a un rapido miglioramento delle condizioni cliniche e alla guarigione. Purtroppo, diversi aspetti sono ancora poco chiari e meritano approfondimenti e ricerche. Ad esempio, non è ancora noto quale sia la quota di pazienti convalescenti Covid-19 in grado di sviluppare una quantità sufficiente di anticorpi, il tempo necessario per la loro comparsa a seguito di infezione e la loro persistenza nel tempo; rimangono da definire gli aspetti qualitativi degli anticorpi responsabili dell’attività protettiva e ‘neutralizzante’ come la classe di IgG e le sottoclassi di IgG coinvolte.

Il progetto di ricerca che vede coinvolti Hamad Medical Corporation (Doha), Mater Olbia Hospital e Università Cattolica del Sacro Cuore, col supporto di Qatar Foundation Endowment, si propone proprio di valutare la sicurezza e l’efficacia della terapia con plasma in una coorte di pazienti Covid-19.

Lo studio ha come obiettivo “la caratterizzazione del ruolo degli anticorpi neutralizzanti nello sviluppo dell’immunità post-Covid-19”, mediante un’analisi dettagliata della risposta anticorpale specifica per Sars-CoV-2. I risultati della ricerca, che prevede l’arruolamento di 100 donatori e 100 pazienti riceventi, contribuiranno in modo significativo a standardizzare e migliorare la terapia con plasma. Ma come si svolge concretamente? Il plasma di pazienti verrà raccolto e infuso su malati con quadri severi da Covid-19 presso l’Hamad Medical Corporation, dove verranno valutati e monitorati i dati clinici dei pazienti. Aliquote di plasma dei pazienti ‘guariti’ sono stati e verranno raccolti in tempi diversi, e lo stesso accade per i riceventi. I campioni di plasma verranno trasmessi al Mater Olbia Hospital per la determinazione qualitativa e quantitativa degli anticorpi anti-Sars-CoV-2.

Presso il Mater Olbia Hospital verranno eseguiti, mediante saggi Elisa, la determinazione dei titoli anticorpali e la caratterizzazione qualitativa della risposta sui campioni di plasma ricevuti da Hamad Medical Corporation (da pazienti donatori e riceventi). In tal modo sarà possibile determinare una cinetica della risposta immunitaria ed i profili immunologici nella coorte di pazienti inclusi nello studio. Sulla base dei risultati ottenuti verranno selezionati dei campioni rappresentativi per la misurazione dell’attività neutralizzante. Presso il Laboratorio di Microbiologia dell’Uiversità Cattolica di Roma verranno eseguiti i test per la determinazione dell’attività neutralizzante del plasma ottenuto da un gruppo selezionato di pazienti donatori e riceventi. I saggi prevedono l’infezione di cellule con virus Sars-CoV-2 e misurazione dell’inibizione dell’infezione dai parti del plasma oggetto dello studio.

La ricerca si propone di individuare i profili della risposta immunitaria umorale (anticorpi) che si associano ad attività protettiva e quindi neutralizzante. I risultati contribuiranno a meglio comprendere i processi immunologici associati alle terapie con plasma iperimmune, trasformando un trattamento attualmente basato su dati prevalentemente empirici in protocolli terapeutici informati e basati evidenze scientifiche, si legge in una nota.

La ricerca è interamente finanziata da Qatar Foundation Endowment, Hamad Medical Corporation e Mater Olbia Hospital e ha un valore stimato di 500.000 euro. Lo studio sarà coordinato da Hussam Al Soub e da Ali S. Omrani di Hamad Medical Corporation e da Stefano Vella, docente di Salute globale Ucsc, e Giovanni Delogu, associato di Microbiologia Ucsc, del Mater Olbia Hospital.